Research

Topics Publications In progress publications Communications

Packages

AnaQol Project PRO-online R Packages Online R-package

Life of the unit

Projects Collaborations PhD thesis Traineeships Traineeships propositions Seminars

Next seminars

28 février 2019 Marianne Bourdon et Cédric Faquet état des lieux des différentes méthodes d’analyse qualitative

29 mars 2019 à définir à définir

Last publications

21 janvier 2019 Forestier B, Anthoine E, Reguiai Z, Fohrer C, Blanchin M (2019) A systematic review of dimensions evaluating patient experience in chronic illness. Health and Quality of Life Outcomes, 17(1): 19.

20 janvier 2019 Bonfils N, Grall-Bronnec M, Caillon J, Limosin F, Benyamina A, Aubin H, Luquiens A (2019) Giving room to subjectivity in understanding and assessing problem gambling: A patient-centered approach focused on quality of life. J Behav Addict: under press.

07 janvier 2019 Lorent M, Maalmi H, Tessier P, Supiot S, Dantan E, Foucher Y (2019) Meta-analysis of predictive models to assess the clinical validity and utility for patient-centered medical decision making: application to the CAncer of the Prostate Risk Assessment (CAPRA). BMC Med Inform Decis Mak, 19(1): .

02 janvier 2019 Caruana E, Foucher Y, Tessier P, Frenel JS, Classe JM, Dantan E (2019) Patient-centered simulations to assess the usefulness of the 70-gene signature for adjuvant chemotherapy administration in early-stage breast cancer. Breast Cancer Res Treat: .

01 décembre 2018 Victorri-Vigneau C, Spiers A, Caillet P, Bruneau M, IGNACE Group , Challet G, Grall-Bronnec M (2018) Opioid antagonists for pharmacological treatment of gambling disorder: Are they relevant?. Curr Neuropharmacol, 16(10): 1418-1432.

Updated

23 janvier 2019

Antoine Vanier

Situation

Poste : Post-Doctoral Researcher in Biostatistics
Institution : University of Nantes
Email : antoine.vanier@univ-nantes.fr

Expériences

I'm a MD (Public Health) as well as a PhD in Biostatistics. I'm currently a full-time post-doctoral researcher within the team and a lecturer in Biostatistics, Epidemiology and Methodology for clinical research in the University of Nantes. My research interests are about the interpretation of Patient-Reported Ouctomes data and the measurement of subjective outcomes (psychometrics). I work on methodological and statistical issues about the detection and measurement of response shift phenomenon. Currently, the main project I'm involved in is about defining and determining the Minimal Clinically Importance Difference (MCID) of a PRO instrument while accounting for response shift occurrence. This is the MIDIPRES project funded by the National Agency for Research (ANR), managed by Jean-Benoit Hardouin (PhD-ScD, Associate Professor of Biostatistics, University of Nantes). In terms of experience, my first university training was starting med-school in the University François-Rabelais of Tours in 2001 as well as a Bachelor degree in Cell and Molecular Biology between 2003 and 2005. Then, I took a break from med-school to pursue a Master Degree in Cognitive Sciences in 2005-2006. This was my first experience in academic research. I did a master internship where I conducted a cross-sectional study on links between personality, psychotrauma and Post-Traumatic Stress Disorder (Research team: Inserm U930 "Brain and Imaging" team 4). This study involved conducting semi-structured interviews and administering questionnaires assessing subjective outcomes to patients in order to collect data to quantitatively analyze them. Thus, during this internship, I discovered methodology for clinical research, biostatistics, data analysis and especially psychometrics (through reading the validation papers of the instruments i've used). Therefore, I developed a keen interest about these topics. So, after finishing undergraduate med-school studies, I've decided to pursue a residency in Public-Health in the University Hospital of Nantes to have a strong training about these aspects in parallel of pursuing a Bachelor and Master Degree in Biostatistics and methodology for clinical research (University of Paris-Sud 11). During the first half of my residency, I've worked on in-hospital public health program assessment, population health state assessment (epidemiology of breast cancer in France (incidence and mortality) using cancer registry data and national mortality data), evaluation of the effectiveness of breast cancer systematic screening, genomics clustering of triple-negative breast cancer and as a methodologist and data analyst for various clinical researches. The second half of my residency was devoted to start academic research on PRO data analyses and response shift phenomenon (I joined the team for a first internship in May 2012). I got my MD in 2013 and joined the University of Pierre and Marie Curie (UPMC Paris 6) as an Assistant Professor in biostatistics as well as the University hospital of "La Pitié-Salpêtrière" in Paris as a medical fellow (data analyst and methodologist for clinical research). In parallel, I've conducted my PhD Thesis in Biostatistics within the research team on the concept and measurement of response shift phenomenon which was defended in October 2016. The works conducted during the thesis have helped me realize I like to tackle methodological issues, conducting simulation studies and working on conceptual issues at the edge between methodological and theoretical (even epistemological) aspects of psychometrics. I've started my post-doctoral contract in November 2016 (4 years contract).

Publications scientifiques

Articles dans une revue internationale

1. Eyzop E, Vanier A, Leboucher J, Morvan M, Poulette M, Grall-Bronnec M, Challet G (2018) Materialism, Financial Motives and Gambling: Examination of an Unexplored Relationship. J Gambl Stud: under press.
2. Mosnier I, Vanier A, Lina-Granade G, Truy E, Bordure P, Marx M, Venail F, Poncet C, Belmin J (2018) Long term cognitive prognosis of profoundly deaf older adults after hearing rehabilitation using cochlear implants. Journal of the American Geriatrics Society, 66(8): 1553-1561.
3. Bernardeschi D, Pyatigorskaya N, Vanier A, Bielle F, Smail M, Sterkers O, Kalamarides M (2018) Role of electrophysiology to guide near-total resection for facial nerve function perservation in large vestibula schwanoma surgery. Journal of Neurosurgery, 128(3): 903-910.
4. Lepère V, Vanier A, Loncar Y, Lemoine L, Vaillant J, Monsel A, Savier E, Coriat P, Eyraud D (2017) Risk factors for pulmonary complications after hepatic resection. Role of intraoperative hemodynamic instability and hepatic ischemia. , 17(1): 84.
5. Molto A, Tézenas du Montcel S, Wendling D, Dougados M, Vanier A, Gossec L (2017) Disease activity trajectories in early axial spondyloarthritis: results from the DESIR cohort. Annals of Rheumatic Diseases, 76(6): 1036-1041.
6. Vanier A, Mariette X, Tubach F, Fautrel B (2017) Cost-effectiveness of TNF-blockers injections spacing for patients with established rheumatoid arthritis in remission: an economic evaluation from the Spacing of TNF-blockers injections in Rheumatoid ArhritiS trial. Value in Health, 20(4): 577-585.
7. Torres R, N'guyen Y, Vanier A, Smail M, Ferray E, Sterkers O, Kalamarides M, Bernardeschi D (2017) Multivariate Analysis of Factors Influencing Facial Nerve Outcome following Microsurgical Resection of Vestibular Schwannoma. Otolaryngology Head and Neck Surgery, 156(3): 525-533.
8. De Seta D, N'guyen Y, Vanier A, Ferray E, Bebear J, Godey B, Robier A, Mondain M, Deguine O, Sterkers O, Mosnier I (2016) Five-Year Hearing Outcomes in Bilateral Simultaneously Cochlear-Implanted Adult Patients. Audiology Neurotology, 21: 261-67.
9. Touhami S, Fardeau C, Vanier A, Zambrowski O, Steinborn R, Simon C, Tézenas du Montcel S, Bodaghi B, Le Hoang P (2016) Birdshot Retinochoroidopathy: Prognostic Factors of Long-term Visual Outcome. Americal Journal of Ophthalmology: [Epub ahead of print].
10. Ali A, Carré A, Hassler C, Spilka S, Vanier A, Barry C, Berthoz S (2016) Risk factors for substances use and misuse among young people in France: What can we learn from the Substance Use Risk Profile Scale?. Drug and Alcohol Dependence, 163: 84-91.
11. Touhami S, Fardeau C, Vanier A, Knoeri J, Simon C, Tézenas du Montcel S, Troumani Y, Bodaghi B, Le Hoang P (2015) Visual Acuity in Birdshot Retinochoroidopathy Evaluation. Americal Journal of Ophthalmology, 160(4): 817-21.
12. Vanier A, Sébille V, Blanchin M, Guilleux A, Hardouin JB (2015) Overall performance of Oort's procedure for response shift detection at item-level: a pilot simulation study. Quality of life research, 24(8): 1799-807.
13. Vanier A, Leplège A, Hardouin JB, Sébille V, Falissard B (2015) Semantic primes theory may be helpful in designing questionnaires such as to prevent response shift. Journal of Clinical Epidemiology, 68(6): 646-654.
14. Guilleux A, Blanchin M, Vanier A, Guillemin F, Falissard B, Schwartz C, Hardouin JB, Sébille V (2015) RespOnse Shift ALgorithm in Item response theory (ROSALI) for response shift detection with missing data in longitudinal patient-reported outcome studies. Quality of life research, 24(3): 553-564.
15. Jézéquel P, Loussouarn D, Guérin-Charbonnel C, Campion L, Vanier A, Gouraud W, Hamza L, Guette C, Valo I, Verrièle V, Campone M (2015) Gene-expression molecular subtyping of triple-negative breast cancer tumours: importance of immune response. Breast Cancer Research, 17: 43.
16. Molinié F, Vanier A, Woronoff AS, Guizard AV, Delafosse P, Velten M, Daubisse-Marillac L, Arveux P, Tretarre B (2014) Trends in breast cancer incidence and mortality in France 1990–2008. Breast Cancer Research Treatment, 147(1): 167-75.
17. Vanier A, Leux C, Allioux C, Billon-Delacourt S, Lombrail P, Molinié F (2013) Are prognostic factors more favorable for breast cancer detected by organized screening than by opportunistic screening or clinical diagnosis? A study in Loire-Atlantique (France). Cancer Epidemiology, 37(5): 683-87.

Chapitres d'ouvrage

1. Vanier A, Falissard B, Sébille V, Hardouin JB (2017) The complexity of interpreting changes observed over time in Health-Related Quality of Life: a short overview of 15 years of research on response shift theory. In Guillemin F, Leplège A, Briançon S, Spitz E, Coste J. Perceived health and adaptation in chronic disease. Stakes and future challenge (Taylor and Francis): 202-230.

Articles dans une revue nationale

1. Molinié F, Vanier A, Tretarre B, Guizard AV, Arveux P, Poillot ML, Woronoff AS, Velten M, Binder-Foucard F, Daubisse-Marillac L, Delafosse P (2012) Incidence du cancer in situ et invasif du sein en France (1990-2008) – Données des registres de cancer (réseau FRANCIM). Bulletin Epidémiologique Hebdomadaire InVS - Numéro Thématique, 35-36-37: 395-98.
2. Vanier A, Paillé C, Abbey H, Berrut G, Lombrail P, Moret L (2011) Évaluation du risque iatrogénique médicamenteux des patients âgés hospitalisés en court-séjour. Ger Psychol Neuropsychiatr Vieil, 9(1): 51-7.

Thèses/Rapports/Mémoires

Participations à des projets

MIDIPRES : Détermination de la différence minimale cliniquement pertinente d’instruments de mesure subjective en présence de Response-Shift

Doctorat

Antoine Vanier : The concept, measurement, and integration of response shift phenomenon in Patient-Reported Outcomes data analyses - On certain methodological and statistical considerations (soutenue le 18 octobre 2016)

Stage dans l'équipe

Encadrement de stages

Communications scientifiques

Communications orales dans un colloque international (idpers=231)

1. Hardouin J.B., Leroy M., Vanier A. The statistical performances of common estimators for Minimal Clinically Important Difference determination of patient-reported outcomes: a simulation study. 25th Annual Conference of the ISOQOL, 25-27 october 2018, Dublin, Ireland, Quality of life research 2018, 27:S17-S18, 2018.
2. Vanier A., Toscano A., Sébille V., Hardouin J.B. What are all the proposed methods to estimate the minimal clinically important difference of a patient-reported outcomes measure? A systematic review. 24th Annual Conference of the ISOQOL, 18-21 october 2017, Philadelphia, USA, Quality of life research 2017, 26:20., 2017.
3. Hardouin J.B., Vanier A., Blanchin M., Sébille V. Minimal clinically important difference determination for patient reported outcomes in presence of esponse shift: the MIDIPRES project. 23th Annual Conference of the ISOQOL, 19-22 october 2016, Copenhaguen, Denmark, Quality of life research 2016, 25:14-15, 2016.
4. Vanier A., Tubach F., Alfaiate T., Mariette X., Fautrel B. Step-down strategy of spacing TNF-blockers injections for established rheumatoid arthritis in remission: a cost-utility analysis based on the STRASS trial. EULAR Annual European Congress of Rheumatology, 10-13 Juin, Rome, 2015.
5. Cowppli A., Vanier A., Molinié F., Leux C., Allioux C., Delacour S., Lombrail P. Are prognostic factors more favorable for breast cancer detected by organized screening than by opportunistic screening or clinical diagnosis? A study in Loire-Atlantique (France). 39è congrès annuel du Groupement des Registres et d’Épidémiologistes de Langue Latine, 28-30 Mai, Genève, 2015.
6. Blanchin M., Guilleux A., Vanier A., Hardouin J.B., Sébille V. Comparison of Item Response Theory and Structural Equation Models for response shift detection at the item level. 21th annual conference of ISOQOL, 15-18 october 2014, Berlin, Germany, Quality of life research 2014, 23: 16-17, 2014.
7. Sébille V., Blanchin M., Guilleux A., Vanier A., Guillemin F., Hardouin J.B. Item Response Theory Models for response shift detection with missing data in patient-reported outcomes in longitudinal clinical studies. Sympsium Response Shift and Missing data. 20th annual conference of the ISOQOL, October 9-12, 2013, Miami (USA), 2013, Quality of life research 2013, 22, 2013.
8. Sébille V., Vanier A., Hardouin J.B. Towards a comparison of response shift methods. 19th Annual Conference of ISOQOL, 24-27 octobre 2012, Budapest, Hongrie, 2012.
9. Vanier A., Leux C., Allioux C., Delacour S., Lombrail P., Molinié F. Caractéristiques des cancers du sein selon le mode de découverte, de 1996 à 2007. Loire-Atlantique. 5è congrès international de l’Association Des Épidémiologistes de Langue Française, 12-14 Septembre, Bruxelles, 2012.
10. Vanier A., Molinié F., Grosclaude P., Le Réseau FRANCIM . Incidence des cancers du sein invasifs et in situ, de 1990 à 2008. France.. 5è congrès international de l’Association Des Épidémiologistes de Langue Française, 12-14 Septembre, Bruxelles, 2012.
11. Champin P., Moret L., Naux E., Vanier A., Demeure Dit Latte D., Asehnoune K. Clinical Impact of quality improvement actions decided in morbidity-mortality reviews (MMR) in intensive care units. International Forum on Quality and Safety in Health Care, Symposium HAS-BMJ, 19 Avril, Nice, 2010.

Poster dans un colloque international (idpers=231)

1. Vanier A., Sébille V., Rouquette A., Hardouin J.B. The quality in reporting of studies determining the Minimal Clinically Important Difference of a patient-reported outcomes: a systematic review and a first proposal of guidelines. 25th Annual Conference of the ISOQOL, 25-27 october 2018, Dublin, Ireland, Quality of life research 2018, 27:S161, 2018.
2. Woaye Hune P., Vanier A., Pottier P., Sébille V., Hardouin J.B. Practical considerations for the Minimal Clinically Important Difference (MCID) determination for Patient Reported Outcomes Measures (PROMs). 24th Annual Conference of the ISOQOL, 18-21 october 2017, Philadelphia, USA, Quality of life research 2017, 26:69-70, 2017.
3. Vanier A., Malatier L., Blanchin M., Hardouin J.B., Sébille V. What can detect Oort's procedure in terms of size of response shift effect when used in various empirical realistic situations at domain-level? A simulation study. 24th Annual Conference of the ISOQOL, 18-21 october 2017, Philadelphia, USA, Quality of life research 2017, 26:71, 2017.
4. Vanier A., Tubach F., Alfaiate T., Mariette X., Fautrel B. Step-down strategy of spacing TNF-blockers injections for established rheumatoid arthritis in remission: a cost-utility analysis based on the STRASS trial. American College of Rheumatology Annual Meeting, 6-11 Novembre, San Francisco, 2015.
5. Blanchin M., Guilleux A., Vanier A., Hardouin J.B., Sébille V. Response shift detection at the item level – A comparison of Item Response Theory and Structural Equation Models-based methods. 22nd Annual Conference of the ISOQOL, 21-24 october 2015, Vancouver, Canada, 2015, Quality of life research 2015, 24: 148, 2015.
6. Molto A., Tézenas du Montcel S., Wendling D., Dougados M., Vanier A., Gossec L. Disease activities trajectories in early axial spondyloarthritis: results from the desir cohort. EULAR Annual European Congress of Rheumatology, 10-13 Juin, Rome, 2015.
7. Vanier A., Sébille V., Blanchin M., Guilleux A., Hardouin J.B. Power and Type-I-Error of global assessment of response shift occurrence using Likelihood-Ratio Test or information criteria in Oort’s procedure: a simulation study. 21th annual conference of ISOQOL, 15-18 october 2014, Berlin, Germany, Quality of life research 2014, 23: 99-100, 2014.
8. Vanier A., Leplège A., Hardouin J.B., Sébille V., Falissard B. Semantic primes: a possible way to avoid Response Shift?. 21th annual conference of ISOQOL, 15-18 october 2014, Berlin, Germany, Quality of life research 2014, 23: 165, 2014.
9. Guilleux A., Blanchin M., Vanier A., Hardouin J.B., Sébille V. Searching for an optimal SEM-based method for response shift detection in longitudinal patient-reported outcomes studies – A simulation study. 21th annual conference of ISOQOL, 15-18 october 2014, Berlin, Germany, Quality of life research 2014, 23: 184, 2014.
10. Molinié F., Vanier A., Woronoff A.S., Guizard A.V., Delafosse P., Velten M. Trends in breast cancer incidence and mortality in France 1990–2008. 39è congress annuel du Groupement des Registres et d’Epidémiologistes de Langue Latine, 28-30 Mai, Genève, 2014.
11. Vanier A., Fontenoy A., Abbey H., Paillé C., Moret L. Is the global Trigger Tool@ useful in routine, in a large french teaching hospital ?. 27th International Conference of the ISQUA (International Society for Quality in Health Care), 10-13 Octobre, Paris, 2010.

Communications orales dans un colloque national (idpers=231)

1. Vanier A., Tubach F., Alfaiate T., Mariette X., Fautrel B. Analyse coût-utilité de l’effet de l’espacement des injections sous-cutanées d’anti-TNF dans la polyarthrite rhumatoïde en rémission : données de l’étude STRASS. 28è congrès de la Société Française de Rhumatologie, 13-15 Décembre, Paris, 2015.
2. Vanier A., Leplège A., Hardouin J.B., Sébille V., Falissard B. Semantic primes, une possibilité pour éviter le Response Shift ?. Chronic diseases, adaptation and perceived health: stakes and future - Young Researchers Days, 3-6 juin 2014, Nancy, 2014.
3. Blanchin M., Guilleux A., Vanier A., Hardouin J.B., Sébille V. Development of a RespOnse Shift ALgorithm in Item response theory (ROSALI) for response shift detection in longitudinal patient-reported outcomes studies. Evaluation et analyse de la qualité de vie : nouveaux développements méthodologiques, 3-4 avril 2014, Montpellier, 2014.
4. Guilleux A., Blanchin M., Vanier A., Hardouin J.B., Sébille V. Comparison of Structural Equations Modeling (SEM) and Item Response Theory (IRT) models to detect and take into account Response-Shift. Quels apports des mathématiques à la mesure de la qualité de vie en oncologie, 11-12 septembre 2012, Marseille, France, 2013.
5. Vanier A., Molinié F., Tretarre B., Guizard A.V., Arveux P., Woronoff A.S., Colonna M., Daubisse-Marillac L., Velten M., Binder-Foucard F., Delafosse P, Grosclaude P. Comparaisons et évolution générale des stades du cancer du sein au diagnostic. Séminaire annuel des programmes nationaux de dépistage organisé du cancer du sein et colorectal (InVS, InCa, DGS), 2 Décembre, Paris, 2011.
6. Molinié F., Vanier A., Tretarre B., Guizard A.V., Arveux P., Woronoff A.S., Colonna M., Daubisse-Marillac L., Velten M., Binder-Foucard F., Delafosse P, Grosclaude P. Les données des registres : évolution des types et des stades de cancers du sein-Focus 50-74 ans. 33è journées de la Société Française de Sénologie et Pathologie Mammaire, 9-11 Novembre, Marseille, 2011.
7. Vanier A., Paillé C., Abbey H., Berrut G., Lombrail P., Moret L. Risque iatrogénique médicamenteux chez le patient âgé : évaluation de la conformité des prescriptions de sortie au CHU de Nantes. 1er congrès annuel du Collège de Liaison des Internes de Santé Publique, 1er Juillet, Paris, 2010.
8. Vanier A., Nys M., Godineau M., Atzeni T., El-Hage W., Michel G. Facteurs cliniques et de personnalité (normale et pathologique) associés à la surexposition à des évènements traumatiques et au développement d’un Etat de Stress Post Traumatique (ESPT). Congrès annuel de la Société Française de Psychologie, 10-12 Septembre, Bordeaux, 2008.

Poster dans un colloque national (idpers=231)

1. Lombar I., Castor F., Suhl J., Vanier A., Rufat P. Création d’un référentiel d’analyse : Evaluation de la qualité du codage de la dépendance en SSR et impact sur le groupage - Hôpital Charles Foix (Ivry-sur-Seine), 2014. 28è journées Evaluation, Management, Organisation, Information, Santé (EMOIS), 26-27 Mars, Nancy, 2015.
2. Guilleux A., Blanchin M., Vanier A., Hardouin J.B., Sébille V. Searching for an optimal SEM-based method for response shift detection in longitudinal patient-reported outcomes studies – A simulation study. Chronic diseases, adaptation and perceived health: stakes and future - Young Researchers Days, 3-6 juin 2014, Nancy, 2014.
3. Thimodent T., Paillé C., Thibault R., Jaccard S., Navas D., Vanier A., Darmaun D., Moret L. Dépistage de la dénutrition au CHU de Nantes : vers une amélioration des pratiques ?. 7è congrès annuel de la Société Française de Santé Publique (SFSP), 2-4 Novembre, Lille, 2011.
4. Vanier A., Paillé C., Abbey H., Berrut G., Lombrail P., Moret L. Risque iatrogénique médicamenteux chez le patient âgé : évaluation de la conformité des prescriptions de sortie au CHU de Nantes. (Communication acceptée). 7è congrès de la Société Française de Santé Publique (SFSP), 2-4 Novembre, Lille, 2011.
5. Quéreux G., Brocard A., Vanier A., Khammari A., Dreno B., NGuyen J.M. Évaluation de l’efficacité d’un dépistage ciblé du mélanome. 5è conférences d'épidémiologie clinique (EPICLIN-5), 5-6 Mai, Marseille, 2011.
6. Thibault R., Jaccard S., Navas D., Vanier A., Paillé C., Moret L., Darmaun D. Dépistage et prévalence de la dénutrition : résultats d’une évaluation des pratiques professionnelles (EPP) dans un CHU. Journées Francophones d’Hépato-Gastroentérologie et d’Oncologie Digestive, 24-27 Mars, Paris, 2011.
7. Nys M., Vanier A., Clochon P., Godineau M., El-Hage W., Michel G. Liens entre personnalité (normale et pathologique) et traumatismes psychiques. Congrès annuel de la Société Française de Psychologie, 10-12 Septembre, Bordeaux, 2008.
8. Vanier A., Michel G., Lecadre A., Belzung C., Camus V., El-Hage W. Étude pilote de liens entre facteurs de personnalité et Etat de Stress Post-Traumatique (EPST). 5è congrès de l'Encéphale, 25-27 Janvier, Paris, 2007.

Communications orales dans un colloque local (idpers=231)

1. Hardouin J.B., Vanier A., Blanchin M., Leroy M., Rouquette A., Sébille V., Toscano A., Woaye Hune P. Comparaison des méthodes de détermination de la différences minimale cliniquement pertinente (MCID) sur des scores issus de données rapportées par les patients (PRO) à l'aide d'études de simulation : le projet MIDIPRES. Séminaire de l'UMR CNRS 5558 "Biométrie et Biologie Evolutive", 2018.
2. Vanier A., Leplège A., Hardouin J.B., Sébille V., Falissard B. Some conceptual issues concerning Response Shift in HRQL measurement. International Workshop “Response Shift and subjective measures in health sciences”, 7 Juin, Journées Scientifiques de l'Université de Nantes, Nantes, 2013.