UMR INSERM 1246 - SPHERE
MethodS in Patients-centered outcomes
and HEalth ResEarch

INSERM Univ Nantes Univ Tours
EA4275-SPHERE
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Life of the unit

Projects Collaborations PhD thesis Traineeships Traineeships propositions Seminars

Next seminars

28 février 2019 Marianne Bourdon et Cédric Faquet état des lieux des différentes méthodes d’analyse qualitative

29 mars 2019 à définir à définir

Last publications

21 janvier 2019 Forestier B, Anthoine E, Reguiai Z, Fohrer C, Blanchin M (2019) A systematic review of dimensions evaluating patient experience in chronic illness. Health and Quality of Life Outcomes, 17(1): 19.

20 janvier 2019 Bonfils N, Grall-Bronnec M, Caillon J, Limosin F, Benyamina A, Aubin H, Luquiens A (2019) Giving room to subjectivity in understanding and assessing problem gambling: A patient-centered approach focused on quality of life. J Behav Addict: under press.

07 janvier 2019 Lorent M, Maalmi H, Tessier P, Supiot S, Dantan E, Foucher Y (2019) Meta-analysis of predictive models to assess the clinical validity and utility for patient-centered medical decision making: application to the CAncer of the Prostate Risk Assessment (CAPRA). BMC Med Inform Decis Mak, 19(1): .

02 janvier 2019 Caruana E, Foucher Y, Tessier P, Frenel JS, Classe JM, Dantan E (2019) Patient-centered simulations to assess the usefulness of the 70-gene signature for adjuvant chemotherapy administration in early-stage breast cancer. Breast Cancer Res Treat: .

01 décembre 2018 Victorri-Vigneau C, Spiers A, Caillet P, Bruneau M, IGNACE Group , Challet G, Grall-Bronnec M (2018) Opioid antagonists for pharmacological treatment of gambling disorder: Are they relevant?. Curr Neuropharmacol, 16(10): 1418-1432.

Updated

12 février 2019

Magali Giral


Situation

Poste : PU-PH
Institution : CHU de Nantes


Publications scientifiques

Articles dans une revue internationale

  • 1. Couvrat-Desvergnes G, Foucher Y, Le Borgne F, Dion A, Mourad G, Garrigue V, Legendre C, Rostaing L, Kamar N, Kessler M, Ladrière M, Morelon E, Buron F, Giral M, Dantan E (2018) Comparison of graft and patient survival according to the transplantation centre policy for 1-year screening biopsy among stable kidney recipients: a propensity score-based study. Nephrol Dial Transplant: .

  • 2. Dantan E, Foucher Y, Lorent M, Giral M, Tessier P (2018) Optimal threshold estimator of a prognostic marker by maximizing a time-dependent expected utility function for a patient-centered stratified medicine. Statistical Methods in Medical Research, 27(6): 1847-1859.

  • 3. Giral M, Renaudin K, Naessens M, Luning R, Anglicheau D, Morelon E, Huneau A, Paul C, Brouard S, Couvrat-Desvergnes G, Foucher Y, Dantan E (2018) The 1-year Renal Biopsy Index: a scoring system to drive biopsy indication at 1-year post-kidney transplantation. Transplant International, 31: 947-955.

  • 4. Querard AH, Le Borgne F, Dion A, Giral M, Mourad G, Garrigue V, Rostaing L, Kamar N, Loupy A, Legendre C, Morelon E, Buron F, Foucher Y, Dantan E (2018) Propensity score-based comparison of the graft failure risk between kidney transplant recipients of standard and expanded criteria donor grafts: towards increasing the pool of marginal donors.. American Journal of Transplantation, 18(5): 1151-1157.

  • 5. Le Borgne F, Combescure C, Gillaizeau F, Giral M, Chapal M, Giraudeau B, Foucher Y (2017) Standardized and weighted time-dependent ROC curves to evaluate the intrinsic prognostic capacities of a marker by taking into account confounding factors. Statistical Methods in Medical Research: 962280217702416. doi: 10.1177/0962280217702416.

  • 6. Le Borgne F, Giraudeau B, Querard AH, Giral M, Foucher Y (2016) Comparisons of the performance of different statistical tests for time-to-event analysis with confounding factors: practical illustrations in kidney transplantation. Stat Med, 35(7): 1103-16.

  • 7. Querard AH, Foucher Y, Combescure C, Dantan E, Larmet D, Lorent M, Pouteau LM, Giral M, Gillaizeau F (2016) Comparison of survival outcomes between Expanded Criteria Donors and Standard Criteria Donors kidney transplant recipients: a systematic review and meta-analysis. Transplant International, 29(4): 403-15.

  • 8. Fournier MC, Foucher Y, Blanche P, Buron F, Giral M, Dantan E (2016) A joint model for longitudinal and time-to-event data to better assess the specific role of donor and recipient factors on long-term kidney transplantation outcomes. European Journal of Epidemiology, 31(5): 469-79.

  • 9. Sébille V, Hardouin JB, Giral M, Bonnaud-Antignac A, Tessier P, Papuchon E, Jobert A, Faurel-Paul E, Gentile S, Cassuto R, Morelon E, Rostaing L, Glotz D, Sberro-Soussan R, Foucher Y, Meurette A (2016) Prospective, multicenter, controlled study of quality of life, psychological adjustment process and medical outcomes of patients receiving a preemptive kidney transplant compared to a similar population of recipients after dialysis. BMC Nephrol, 17(1): 11.

  • 10. Couvrat-Desvergnes G, Salama A, Le Berre L, Evanno G, Viklicky O, Hruba P, Vesely P, Guerif P, Dejoie T, Rousse J, Nicot A, Basch J, Ang E, Foucher Y, Brouard S, Castagnet S, Giral M, Perreault H, Lorent M, Soulillou JP (2015) Rabbit antithymocyte globulin-induced serum sickness disease and human kidney graft survival. J Clin Invest, 125(12): .

  • 11. Le Fur A, Fournier MC, Gillaizeau F, Masson D, Giral M, Cariou B, Cantarovich D, Dantal J (2015) Vitamin D deficiency is an independent risk factor for PTDM after kidney transplantation.. Transplant international: .

  • 12. Chapal M, Foucher Y, Marquette C, Néau K, Papuchon E, Daguin P, Morelon E, Mourad G, Castillo J, Ladrière M, Legendre C, Giral M (2015) PREventing Delayed Graft Function by Driving Immunosuppressive InduCtion Treatment (PREDICT-DGF): study protocol for a randomized controlled trial. Trials, 16(1): 282.

  • 13. Gillaizeau F, Dantan E, Giral M, Foucher Y (2015) A multistate additive relative survival semi-Markov model. Statistical Methods in Medical Research, 26(4): 1700-1711.

  • 14. Foucher Y, Meurette A, Daguin P, Bonnaud-Antignac A, Hardouin JB, Néau K, Papuchon E, Guaboriau S, Legendre C, Morelon E, Tessier P, Giral M (2015) A Personalized Follow-up of Kidney Transplant Recipients by Using Video Conferencing based on a 1-year scoring system predictive of long term graft failure (TELEGRAFT study): Protocol for a Randomized Controlled Trial. BMC Nephrology, 16(1): 6.

  • 15. Chapal M, Le Borgne F, Legendre C, Kreiss H, Mourad G, Garrigue V, Morelon E, Buron F, Rostaing L, Kamar N, Kessler M, Ladrière M, Soulillou JP, Launay K, Daguin P, Offredo L, Giral M, Foucher Y (2014) A useful scoring system for the prediction and management of delayed graft function following kidney transplantation from cadaveric donors. Kidney International, 86(6): 1130-9.

  • 16. Debout A, Foucher Y, Trébern-Launay K, Legendre C, Kreiss H, Mourad G, Garrigue V, Morelon E, Buron F, Rostaing L, Kamar N, Kessler M, Ladrière M, Poignas A, Blidi A, Soulillou JP, Giral M, Dantan E (2014) Each additional hour of Cold Ischemia Time significantly increases the risk of graft failure and mortality after renal transplantation. Kidney International, 87: 343-9.

  • 17. Yap M, Boeffard F, Clave E, Pallier A, Danger R, Giral M, Dantal J, Foucher Y, Guillot-Gueguen C, Toubert A, Soulillou JP, Degauque N (2014) Expansion of Highly Differentiated Cytotoxic Terminally Differentiated Effector Memory CD8+ T Cells in a Subset of Clinically Stable Kidney Transplant Recipients: A Potential Marker for Late Graft Dysfunction. J Am Soc Nephrol, 25(8): 1856-68.

  • 18. Lorent M, Giral M, Foucher Y (2014) Net time-dependent ROC curves: a solution for evaluating the accuracy of a marker to predict disease-related mortality. Statistics in Medicine, 33(14): 2379-89.

  • 19. Dantan E, Combescure C, Lorent M, Ashton-Chess J, Daguin P, Classe JM, Giral M, Foucher Y (2014) An original approach was used to better evaluate the capacity of a prognostic marker using published survival curves. Journal of Clinical Epidemiology, 67(4): 441-8.

  • 20. Foucher Y, Akl A, Rousseau V, Trébern-Launay K, Lorent M, Kessler M, Ladrière M, Legendre C, Kreiss H, Rostaing L, Kamar N, Mourad G, Garrigue V, Morelon E, Daurès JP, Soulillou JP, Giral M (2014) An alternative approach to estimate age-related mortality of kidney transplant recipients compared to the general population: results in favor of old-to-old transplantations. Transplant International, 27(2): 219-25.

  • 21. Chapal M, Néel M, Le Borgne F, Meffray E, Carceles O, Hourmant M, Giral M, Foucher Y, Moreau A, Fakhouri F (2013) Increased soluble flt-1 correlates with delayed graft function and early loss of peritubular capillaries in the kidney graft. Transplantation, 96(8): 739-44.

  • 22. Giral M, Foucher Y, Dufay A, Duong Van Huyen J, Renaudin K, Moreau A, Philippe A, Hegner B, Dechend R, Brouard S, Cesbron A, Castagnet S, Devys A, Soulillou JP, Dragun D (2013) Pretransplant Sensitization Against Angiotensin II Type 1 Receptor Is a Risk Factor for Acute Rejection and Graft Loss. American Journal of Transplantation, 13(10): 2567-76.

  • 23. Trébern-Launay K, Giral M, Dantal J, Foucher Y (2013) Comparison of the risk factors effects between two populations: two alternative approaches illustrated by the analysis of first and second kidney transplant recipients. BMC Medical Research Methodology, 13: 102.

  • 24. Cantarovich D, Hodemon-Corne B, Trébern-Launay K, Giral M, Foucher Y, Dantan E (2013) Early steroid withdrawal compared with steroid avoidance correlates with graft failure among kidney transplant recipients with an history of diabetes. Transplantation Procedings, 45(4): 1497-502.

  • 25. Danger R, Paul C, Giral M, Foucher Y, Degauque N, Pallier A, Durand M, Castagnet S, Duong Van Huyen J, Delahousse M, Renaudin K, Soulillou JP, Brouard S (2013) Expression of miR-142-5p in peripheral blood mononuclear cells from renal transplant patients with chronic antibody-mediated rejection. PLoS One, 8(4): e60702.

  • 26. Trébern-Launay K, Foucher Y, Giral M, Legendre C, Kreiss H, Kessler M, Ladrière M, Kamar N, Rostaing L, Garrigue V, Mourad G, Morelon E, Soulillou JP, Dantal J (2012) Poor long-term outcome in second kidney transplantation : a delayed event. PLoS One, 7(10): e47915.

  • 27. Thibaud A, Foucher Y, Danger R, Migone T, Pallier A, Castelli C, Castagnet S, Devys A, Cesbron A, Giral M, Soulillou JP, Brouard S (2012) BAFF and BAFF-R levels are associated with risk of long-term kidney graft dysfunction and development of donor-specific antibodies. Am J Transplant, 12(10): 2754-62.

  • 28. Foucher Y, Combescure C, Ashton-Chess J, Giral M (2012) Prognostic Markers: Data Misinterpretation Often Leads to Overoptimistic Conclusions. Am J Transplant, 12(4): 1060-1.

  • 29. Foucher Y, Giral M, Soulillou JP, Daurès JP (2012) Cut-off estimation and medical decision making based on a continuous prognostic factor : the prediction of kidney graft failure. Int J Biostat, 8(1): 1–13.

  • 30. Brouard S, Le Bars A, Dufay A, Gosselin M, Foucher Y, Guillet M, Cesbron A, Thervet E, Legendre C, Dugast E, Pallier A, Guillot-Gueguen C, Lagoutte L, Evanno G, Giral M, Soulillou JP (2011) Identification of a gene expression profile associated with operational tolerance among a selected group of stable kidney transplant patients. Transplantation International, 24(6): 536-547.

  • 31. Racapé M, Duong Van Huyen J, Danger R, Giral M, Bleicher F, Foucher Y, Pallier A, Pilet P, Tafelmeyer P, Ashton-Chess J, Dugast E, Pettre S, Charreau B, Soulillou JP, Brouard S (2011) The involvement of SMILE/TMTC3 in endoplasmic reticulum stress response. PLoS One, 6(5): e19321.

  • 32. Foucher Y, Giral M, Soulillou JP, Daurès JP (2010) Time-dependent ROC analysis for a three-class prognostic with application to kidney transplantation. Statistics in Medicine, 29(30): 3079-87.

  • 33. Foucher Y, Daguin P, Akl A, Kessler M, Ladrière M, Legendre C, Kreiss H, Kamar N, Rostaing L, Garrigue V, Bayle F, de Ligny B, Buchler M, Meier C, Soulillou JP, Giral M (2010) A clinical scoring system highly predictive of long-term kidney graft survival.. Kidney International, 78(12): 1288-94.

  • 34. Miqueu P, Degauque N, Guillet M, Giral M, Ruiz C, Pallier A, Braudeau C, Roussey-Kesler , Asthon-chess J, Dore J, Thervet E, Legendre C, Hernandez-Fuentez MP, Warrens A, Volk HD, Janssen U, Wood KJ, Lechler RI, Bertrand D, Sébille V (2010) Analysis of the peripheral T cell repertoire in kidney transplant patients. European Journal of Immunology, 40(11): 3280-3290.

  • 35. Giral M, Foucher Y, Karam G, Labrune Y, Kessler M, de Ligny B, Buchler M, Bayle F, Meyer C, Trehet N, Daguin P, Renaudin K, Moreau A, Soulillou JP (2010) Kidney and recipient weight incompatibility reduces long-term graft survival. Journal of the American Society of Nephrology, 21(6): 1022-9.

  • 36. Asthon-chess J, Mai H, Jovanovic V, Renaudin K, Foucher Y, Giral M, Moreau A, Dugast E, Mengel M, Racapé M, Danger R, Usual C, Smith H, Guillet M, Gwinner W, Le Berre L, Dantal J, Soulillou JP, Brouard S (2010) Immunoproteasome beta subunit 10 is increased in chronic antibody-mediated rejection.. Kidney International, 77(10): 880-90.

  • 37. Foucher Y, Giral M, Soulillou JP, Daurès JP (2010) A flexible semi-Markov model for interval-censored data and goodness-of-fit testing. Statistical Methods in Medical Research, 19(2): 127-45.

  • 38. Foucher Y, Giral M, Soulillou JP, Daurès JP (2010) Cut-off estimation and medical decision making based on a continuous prognostic factor: the prediction of kidney graft failure. International Journal of Biostatistics, 8(1): article 1.

  • 39. Asthon-chess J, Dugast E, Colvin R, Giral M, Foucher Y, Moreau A, Renaudin K, Braud C, Devys A, Brouard S, Soulillou JP (2009) Regulatory, effector, and cytotoxic T cell profiles in long-term kidney transplant patients. Journal of the American Society of Nephrology, 20(5): 1113-22.

  • 40. Rousseau V, Foucher Y, Giral M, Soulillou JP, Daurès JP (2009) Informative censoring in a multiplicative relative survival model: application for kidney transplant recipients. JP Journal of Biostatistics, 3(3): 195-214.

  • 41. Asthon-chess J, Giral M, Mengel M, Renaudin K, Foucher Y, Gwinner W, Braud C, Dugast E, Quillard T, Thebault P, Chiffoleau E, Braudeau C, Charreau B, Soulillou JP, Brouard S (2008) Tribbles-1 as a Novel Biomarker of Chronic Antibody-Mediated Rejection. Journal of the American Society of Nephrology, 19(6): 1116-27.

  • 42. Foucher Y, Daguin P, Kessler M, Laveyssiere L, Legendre C, Kreiss H, Durand D, Layrolle P, Mourad G, Garrigue V, Daurès JP, Soulillou JP, Giral M (2008) How to evaluate the long-term prognostic capacity of pre-graft variables in transplantation?. Clinical Transplant: 113-8.

  • 43. Foucher Y, Giral M, Soulillou JP, Daurès JP (2007) A semi-Markov model for multistate and interval-censored data with multiple terminal events. Application in renal transplantatio. Statistics in Medicine, 26(30): 5381-93.

  • 44. Giral M, Bertola JP, Foucher Y, Villers D, Bironneau E, Blanloeil Y, Karam G, Daguin P, Lerat L, Soulillou JP (2007) Effect of brain-dead donor resuscitation on delayed graft function: results of a monocentric analysis. Transplantation, 83(9): 1174-81.

  • 45. Ballet C, Roussey-Kesler , Aubin JT, Brouard S, Giral M, Miqueu P, Louis S, van der Werf S, Soulillou JP (2006) Humoral and cellular responses to influenza vaccination in human recipients naturally tolerant to a kidney allograft. Am J of Transplantation, 6(11): 2796-2801.

  • 46. Giral M, NGuyen JM, Karam G, Kessler M, Hurault de Ligny B, Buchler M, Bayle F, Meyer C, Foucher Y, Martin ML, Daguin P, Soulillou JP (2005) Impact of graft mass in the clinical outcome of kidney transplants. Journal of the American Society of Nephrology, 16: 261-268.

Chapitres d'ouvrage

  • 1. Ladrière M, Foucher Y, Legendre C, Kamar N, Garrigue V, Morelon E, Kressler M, Soulillou JP, Giral M (2010) The Western Europe Cohort Of Kidney Transplanted Recipients - The DIVAT Network. In Clinical Transplants (J. Michael Cecka and Paul I. Terasaki): Terasaki Foundation Laboratory.

  • 2. Foucher Y, Daguin P, Kessler M, Ladrière M, Legendre C, Kreiss H, Durand D, Mourad G, Garrigue V, Soulillou JP, Giral M (2008) How well do pre- and peritransplant variables predict the long-term results of kidney transplantation?. In Clinical Transplants - Chapter 10 (J. Michael Cecka and Paul I. Terasaki): Terasaki Foundation Laboratory.

Articles dans une revue nationale

  • 1. Gillaizeau F, Giral M, Dantan E, Dragun D, Soulillou JP, Foucher Y (2014) Multi-state analysis of kidney transplant recipients outcome: a semi-Markov model for studying the role of pre-transplant sensitization against Angiotensin II Type 1 receptor. Journal de la Société Française de Statistique , 155(1): 117-133.


Participations à des projets

  • DIVAT-SPHERE - Axe 2 : Prédiction/pronostic à long-terme du patient transplanté

  • DIVAT-SPHERE - Axe 1 : Système d'information - Qualité des données


Encadrement/Accompagnement de thèses

  • Marie-Cécile Fournier : Pronostic dynamique de l’évolution de l’état de santé de patients atteints d’une maladie chronique : une approche par modélisation conjointe (soutenue le 10 octobre 2016)

  • Florent Le Borgne : Conception d’un outil simple permettant des analyses statistiques ajustées pour la valorisation des données de cohortes observationnelles de pathologies chroniques : application à la cohorte DIVAT. (soutenue le 30 septembre 2016)

  • Florence Gillaizeau : Développement et validation de modèles multi-états semi-markovien pour le pronostic de patients atteints de maladies chroniques: application à la cohorte DIVAT de patients transplantés rénaux (soutenue le 15 octobre 2015)

  • Marine Lorent : Construction d'un marqueur composite de substitution de la survie à long terme appliqué à la transplantation rénale (soutenue le 19 novembre 2014)

  • Katy Trébern-Launay : Apport des modèles de survie relative dans la modélisation des patients transplantés rénaux : application à la cohorte DIVAT (soutenue le 24 octobre 2013)


Encadrement de stages

  • Alexandre Huneau : Score diagnostique de la normalité anatomo-pathologique sur les biopsies de surveillance des greffons rénaux à un an post-transplantation (2014)

  • Chloé Rousseau : Construction d’un score biologique diagnostique de la normalité de la biopsie à un an de greffe :Application à la transplantation rénale (2013)

  • Damien Drubay : Modélisation conjointe de l'évolution de la fonction rénale et de la survie patient/greffon chez des patients greffés rénaux. Influence du poids du rein (2011)

  • Marine Lorent : Facteurs de risque liés au changement de traitement immunosuppresseur dans la première année de la greffe rénale (2010)

  • Katy Trébern-Launay : Analyse de l'excès de risque d'échec des secondes greffes rénales par rapport aux premières. (2010)


Communications scientifiques

Communications orales dans un colloque international (idpers=180)

  • 1. Querard A.H., Le Borgne F., Giral M., Foucher Y., Dantan E. Propensity score-based comparison of the graft failure risk between kidney transplant recipients of standard and expanded criteria donor grafts: towards increasing the pool of marginal donors. Congrès Européen de Transplantation (ESOT) Barcelone , 2017.

  • 2. Giral M., Renaudin K., Legendre C., Kreis H., Morelon E., Buron F., Naessens M., Luning R., Huneau A., Brouard S., Brouard S., Couvrat-Desvergnes G., Foucher Y., Dantan E.. The One year Renal Biopsy Index (1-RBI): a clinical marker to screen patients for one year surveillance biopsy indication after the transplantation. 26th International Congress of The Transplantation Society, 18th-23th August, Hong-Kong, 2016.

  • 3. Gillaizeau F., Dantan E., Giral M., Foucher Y. Additive relative survival multistate semi-Markov model. International Society for Clinical Biostatistics, 35th Annual Conference, Vienna, Austria, 2014.

  • 4. Dantal J., Le Fur A., Fournier M.C., Masson D., Gillaizeau F., Giral M. Vitamin D deficiency is a new independent risk factor of NODAT for kidney transplant recipients . World transplant congress, 26-31 juillet 2014, San Francisco, Transplantation 2014;98 Suppl 1:94-94, 2014.

  • 5. Le Fur A., Fournier M.C., Masson D., Gillaizeau F., Giral M., Dantal J. Vitamin D as novel risk factor of NODAT. Société Francophone de Transplantation, 11-14 décembre 2013, Marrakech, Transplant International 2013;26 Suppl 3:19-19, 2013.

  • 6. Gillaizeau F., Foucher Y., Dragun D., Soulillou J.P., Dufay A., Van Huyen J., Renaudin K., Moreau A., Dantan E., Giral M. A multistate model to investigate the relationship between pre-graft level of Angiotensin II Type 1 Receptor (AT1R) antibodies and kidney transplant recipients outcome. American Transplant Congress, Seattle, American Journal of Transplantation 2013;13 Suppl 5:194-194, 2013.

  • 7. Trébern-Launay K., Giral M., Foucher Y. Multiplicative-regression model to compare the effect of factors associated with the time to graft failure between first and second renal transplant. International Society for Clinical Biostatistics, Bergen, Norway, August 23-27, 2012.

  • 8. Dantan E., Combescure C., Ashton-Chess J., Lorent M., Giral M., Foucher Y. How to evaluate the prognostic capacity of surrogate makers?. The British Transplant Society, Glasgow, 2012.

  • 9. Harzallah k., Frimat L., Giral M., Foucher Y., Soulillou J.P., Dantal J. Induction Therapy Is Not Associated with Increasing Risk of Cancer After Renal Transplantation . The Federation of Clinical Immunology Societies (FOCIS), 2012.

  • 10. Lorent M., Giral M., Foucher Y. Relative ROC curves: a solution for evaluating the accuracy of a marker to predict the cause-specific mortality. International Society for Clinical Biostatistics, 2012, Bergen, 2012.

  • 11. Degauque N., Boeffard F., Foucher Y., Pallier A., Danger R., Dantal J., Giral M., Brouard S., Soulillou J.P. Altered TCR Vb Repertoire Identifies Kidney Recipient with a Higher Risk of Graft Dysfunction. American Transplant Congress, 2012, Boston, 2012.

  • 12. Giral M., Akl A., Rousseau V., Launay K., Daguin P., Kessler M., Ladrière M., Legendre C., Kreiss H., Rostaing L., Kamar N., Mourad G., Garrigue V., Morelon E., Pasturel M., Daures JP., Soulillou JP., Foucher Y. A Relative Survival Modelisation on Both European (DIVAT) and American (UNOS) Data Banks Allows To Appraise the Mortality Specifically Linked to the Kidney Transplantation Status. American Transplant Congress (Boston), 2012, 2012.

  • 13. Gillaizeau F., Dragun D., Soulillou J.P., Dufay A., Van Huyen J., Renaudin K., Moreau A., Giral M., Foucher Y. A Semi-Markov model with Generalized Weibull distribution for multistate data in kidney transplant recipients. Congrès Annuel de la Société Francophone de Transplantation, 2012, Nantes, Transplant International 2012;25 Suppl 2:34-34, 2012.

  • 14. Gillaizeau F., Giral M., Dantan E., Dragun D., Soulillou J.P., Foucher Y. A Semi-Markov model with Generalized Weibull distribution for multistate data in kidney transplant recipients. Journées 2012 de la Société Française de Biométrie, Paris, 2012.

  • 15. Akl A., Giral M., Rousseau V., Kessler M., Ladrière M., Legendre C., Kreiss H., Rostaing L., Kamar N., Mourad G., Garrigue V, Daures JP, Soulillou JP, Foucher Y. A relative survival model to assess the specific mortality related to renal transplantation. European Society for Organ Transplantation (ESOT) Congress, Septembre 2011, 2011.

  • 16. Trébern-Launay K., Foucher Y., Giral M., Legendre C., Kessler M., Kamar N., Garrigue V., Morelon E., Dantal J. Poor outcome of second kidney transplantation: a delayed event. European Society for Organ Transplantation (ESOT) Congress, Glasgow, UK, September 4-7, 2011.

  • 17. Cantarovich D., Hodemon-Corne B., Dantan E., Trébern-Launay K., Karam G., Giral M. Corticosteroid avoidance or withdrawal: which immunosuppression is better after renal transplantation?. American Transplant Congress (ATC), Philadelphia, USA, May 1-4 , 2011.

  • 18. Mai H., Giral M., Launay K., Foucher Y., Garrigue V., Legendre C., Kamar N., Kessler M., Morelon E., Hourmant M., Brouard S., Soulilou J.P.. Kidney after Nonrenal Organ Transplantation-Analysis of a 15-Year Multicenter Cohort. American Transplant Congress, Avril 2011, Philadelphia, 2011.

  • 19. Danger R., Lavault A., Giral M., Van Huyen J., Foucher Y., Pallier A., Degauque N., Soulillou J.P., Brouard S. Over-Expression in Blood and Kidney Graft from Patients Exhibiting Chronic Antibody Mediated Rejection. American Transplant Congress, Avril 2011, Philadelphia, 2011.

  • 20. Hegner B., Giral M., Dufay A., Van Huyen J., Foucher Y., Renaudin K., Moreau A., Philippe A., Dechend R., Heidecke H., Cesbron A., Devys A., Soulillou J. P. . Pre-transplant sensitization against angiotensin II Type 1 receptor is a novel independent risk factor of antibody-mediated tejection. uropean Society for Organ Transplantation (ESOT) Congress, Octobre 2011, 2011.

  • 21. Foucher Y., Rigouin P., Trébern-Launay K., Akl A., Landais P., Duny Y., Daurès J.P., Giral M. The modeling of the evolution of kidney transplant recipients : Applications to the DIVAT cohort. International Society for Clinical Biostatistics, Montpellier, France, August 29-September 2, 2010.

  • 22. Danger R., Giral M., Foucher Y., Pallier A., Degauque N., Soulillou J.P., Brouard S. miRNA Signatures in Blood of Kidney Transplant Recipients. 10th American Transplant Congress, 2010.

  • 23. Racapé M., Van Huyen J., Danger R., Giral M., Foucher Y., Bleicher F., Pallier A., Tafelmeyer P., Asthon-chess J., Soulillou J.P., 10th American Transplant Congress. SMILE, a New Molecule Overexpressed in the Blood of Operationally Tolerant Patients, Is Involved in Endoplasmic Reticulum Stress Response. , 2010.

  • 24. Giral M., Dufay A., Van Huyen J., Foucher Y., Philippe A., Heidecke H., Cesbron A., Devys A., Soulillou J.P., Dragun D. Pre-Transplantation Non-HLA Immunisation Against Angiotensin II Type 1 Receptor (AT(1)R-Antibody) Is an Independent Risk Factor of Early Acute Rejection. 10th American Transplant Congress, 2010.

  • 25. Foucher Y., Giral M., Soulillou J.P., Daurès J.P., International Society for Clinical Biostatistics . Time-dependent ROC analysis for a three-class prognostic. , 2009.

  • 26. Ashton-Chess J., Dugast E., Colvin R., Giral M., Foucher Y., Moreau A., Renaudin K., Braud C., Devys A., Brouard S., Soulilou J.P.. Regulatory, Effector, and Cytotoxic T Cell Profiles in Long-Term Kidney Transplant Patients. 8th American Transplant Congress, 2009, Toronto, 2009.

  • 27. Foucher Y., Giral M., Soulillou J.P., Daurès J.P. Time-dependent ROC analysis for a three-class prognostic. International Society for Clinical Biostatistics, 2009, Prague, 2009.

  • 28. Giral M., Foucher Y., Labrune Y., Karam G., Kessler M., Hurault de Ligny B., Buchler M., Bayle F., Meyer C., Daguin P., Soulilou J.P.. Kidney and recipient weight incompatibility: a cause of early proteinuria and reduced long-term graft survival. American Transplant Congress, 2009, Boston, 2009.

  • 29. Foucher Y., Giral M., Soulillou J.P., Daurès J.P. An adaptation of time-dependent ROC curves to construct a prognosis test based on the repetition of a surrogate marker: Application on the kidney graft failure and the creatinine clearance. International Society for Clinical Biostatistics (Copenhague), 2008.

  • 30. Asthon-chess J., Dugast E., Colvin R., Giral M., Foucher Y., Moreau A., Renaudin K., Braud C., Brouard S., Soulillou J.P. Regulatory, effector, and cytotoxic T cell profiles in long-term kidney transplant patients. 8th American Transplant Congress, 2008.

  • 31. Asthon-chess J., Jovanovic V., Foucher Y., Dugast E., Giral M., Renaudin K., Heslan M., Soulillou J.P., Brouard S. The immunoproteasome subunit beta 10 as a novel peripheral blood and intragraft biomarker of chronic antibody mediated allograft rejection in clinical transplantation. American Transplant Congress (Toronto), 2008.

  • 32. Giral M., Foucher Y., Daurès J.P., Soulillou J.P. New tool to analyse confounding factors in kidney graft outcome: A DIVAT data base study. American Transplant Congress, 2008, Toronto, 2008.

  • 33. Ashton-Chess J., Jovanovic V., Foucher Y., Dugast E., Giral M., Renaudin K., Heslan M., Soulillou J.P., Brouard S. The immunoproteasome subunit beta 10 as a novel peripheral blood and intragraft biomarker of chronic antibody mediated allograft rejection in clinical transplantation. American Transplant Congress, 2008, Toronto, 2008.

  • 34. Foucher Y., Soulillou J.P., Daurès J.P., Giral M. Longitudinal analysis of kidney transplant recipients with multi-state model. Annual American Transplant Congress, 2007.

  • 35. Foucher Y., Giral M., Soulillou J.P., Daurès J.P. A semi-Markov model for interval-censored data and multiple event: Application to the evolution of kidney transplant recipients. 27th Annual Conference of the International Society for Clinical Biostatistics (ISCB), 2006.

  • 36. Foucher Y., Giral M., Soulillou J.P., Daurès J.P. A semi-Markov Model with Interval Censoring and Non-Proportional Hazards. 23th International Biometric Conference, 2006.

  • 37. Asthon-chess J., Giral M., Braud C., Baeten D., Heslan M., Chiffoleau E., Foucher Y., Soulillou J.P., Brouard S. Tribbles homolog 1, a peripheral blood marker of chronic rejection in clinical renal allotransplantation identified by transcriptome profiling: role and correlation with renal histology and function. World transplant congress, 2006.

  • 38. Giral M., Foucher Y., Karam G., NGuyen J.M., de Ligny B., Buchler M., Bayle F., Meyer C., Martin M.L., Soulillou J.P. Impact of graft mass on the clinical outcome of kidney transplants. Annual American Transplant Congress, 2004.

Poster dans un colloque international (idpers=180)

  • 1. Enjalbert L., Hardouin J.B., Blanchin M., Giral M., Meurette A., Sébille V. Evaluation of quality of life changes in patients on waiting list for kidney transplantation using growth mixture models coupled with latent class analysis. 25th Annual Conference of the ISOQOL, 25-27 october 2018, Dublin, Ireland, Quality of life research 2018, 27:S144-S145, 2018.

  • 2. Enjalbert L., Hardouin J.B., Giral M., Meurette A., Sébille V. . Comparison of quality of life in pre-emptive and dialyzed patients on waiting list for kidney transplantation. Exploring differential item functioning using Rasch Measurement Theory Models. 24th Annual Conference of the ISOQOL, 18-21 october 2017, Philadelphia, USA, Quality of life research 2017, 26:128-129, 2017.

  • 3. Sébille V., Hardouin J.B., Tessier P., Bonnaud-Antignac A., Giral M., Meurette A. A. Comparison of quality of life of pre-emptive or dialyzed patients on waiting list for kidney transplantation. prospective, observational, multicenter controlled study. Is differential item functioning occurring and is it an issue for the comparison?. 23h Annual Conference of the ISOQOL, 19-22 october 2016, Copenhaguen, Denmark, Quality of life research 2016, 25: 145, 2016.

  • 4. Couvrat-Desvergnes G., Giral M., Dantan E. Clinical utility of surveillance kidney transplant biopsies at 1-year post-transplantation: a long-term survival comparison among renal transplant recipients. 26th International Congress of The Transplantation Society, 18th-23th August, Hong-Kong, 2016.

  • 5. Gillaizeau F., Le Borgne F., Rousseau C., Leyrat C., Giral M., Chapal M., Barbin L., Laplaud D., Giraudeau B., Foucher Y. The traditional multivariable logistic regression compared to propensity score: a study to put an end to preconceived ideas. 4th annual meeting of the UK Causal Inference Meeting, 13th-15th April 2016, London, 2016.

  • 6. Sébille V., Hardouin J.B., Bonnaud-Antignac A., Tessier P., Giral M., Foucher Y., Meurette A. A. Response shift in patients receiving a pre-emptive kidney transplant compared to similar recipients having experienced a short dialysis period: study protocol for a prospective, observational, multicenter controlled study. 22th Annual Conference of the ISOQOL, 21-24 october 2016, Vancouver, Canada, Quality of life research 2015, 24: 63, 2015.

  • 7. Querard A.H., Gillaizeau F., Couvrat-Desvergnes G., Dantal J., Daguin P., Le Floch S., Castagnet S., Brouard S., Foucher Y., Giral M. . American Transplant Congress, May 2-6 2015, Philadelphia, 2015.

  • 8. Querard A.H., Foucher Y., Combescure C., Dantan E., Larmet D., Lorent M., Pouteau L.M., Giral M., Gillaizeau F. Comparison of survival outcomes between Expanded Criteria Donors and Standard Criteria Donors kidney transplant recipients: a systematic review and meta-analysis. American Transplant Congress, May 2-6 2015, Philadelphia, 2015.

  • 9. Fournier M.C., Dantan E., Foucher Y., Giral M. A joint survival longitudinal approach to better assess the etiological role of risk factors of kidney transplant graft failure. American transplant congress, 2-6 mai 2015, Philadelphia, 2015.

  • 10. Dantan E., Renaudin K., Brouard S., Huneau A., Paul C., Couvrat-Desvergnes G., Giral M. A clinical signature surrogate of histological lesions to avoid unnecessary one year surveillance biopsy after renal transplantation. American Transplant Congress, May 2-6 2015, Philadelphia, 2015.

  • 11. Trébern-Launay K., Foucher Y., Giral M., Bayat-Makoei S., Kessler M. Competing Risks of Death and Transplantation for ESRD Patients Waitlisted: a Mixture Model opening new Perspectives in Graft Allocation. AST-ESOT Congress, Madrid, Spain, October 17-19, 2014.

  • 12. Querard A.H., Gillaizeau F., Pouteau L.M., Foucher Y., Larmet D., Dantan E., Lorent M., Combescure C., Giral M. Expanded Criteria Donor in Kidney Transplantation : a meta-analysis. European Society for Organ Transplantation, 17-19 October 2014, Madrid, 2014.

  • 13. Trébern-Launay K., Foucher Y., Dantal J., Giral M. A multiplicative-regression model to compare the risk factors associated with time to graft failure between a first and second renal transplant. European Society for Organ Transplantation (ESOT), Vienna, Austria, September 8-11, 2013.

  • 14. Lorent M., Foucher Y., Giral M. Net time-dependent ROC curves : a new method for evaluating the accuracy of a marker to predict mortality related to end-stage renal disease in kidney transplant recipients.. European Society for Organ Transplantation (ESOT), September 2013, Vienna (Austria), 2013.

  • 15. Trébern-Launay K., Foucher Y., Dantal J., Giral M. A multiplicative-regression model to compare the risk factors associated with time to graft failure between a first and second renal transplant. American Transplant Congress (ATC), Seattle, USA, May 18-22, 2013.

  • 16. Lorent M., Foucher Y., Giral M. Net time-dependent ROC curves : a new method for evaluating the accuracy of a marker to predict mortality related to end-stage renal disease in kidney transplant recipients.. American Transplant Congress (ATC), May 2013, Seattle (USA), 2013.

Communications orales dans un colloque national (idpers=180)

  • 1. Fournier M.C., Foucher Y., Giral M., Dantan E. Dynamic predictions of long-term kidney graft failure: an information tool promoting patient-centered care. Autumn School DHU2020, 2018.

  • 2. Fournier M.C., Foucher Y., Giral M., Dantan E. Une application Shiny pour prédire dynamiquement la survie patient-greffon d’un patient transplanté rénal : vers une décision médicale plus partagée. 7e rencontres R - Rennes, 2018.

  • 3. Fournier M.C., Foucher Y., Giral M., Dantan E. Prédictions dynamiques du risque d’échec de greffe : un outil pour aider à l’information des patients transplantés rénaux et une prise en charge centrée sur le patient et ses attentes.. 12e conférence francophone d'épidémiologie clinique (EPICLIN 2018) et 25e journées des statisticiens des centres de lutte contre le cancer, 30 mai 2018, Nice, RESP, 2018.

  • 4. Le Borgne F., Combescure C., Gillaizeau F., Giral M., Chapal M., Giraudeau B., Foucher Y. Courbes ROC standardisées dépendantes du temps pour évaluer les capacités pronostiques inhérentes à un marqueur en tenant compte des facteurs de confusion.. EPICLIN 2016 Strasbourg, 2016.

  • 5. Gillaizeau F., Le Borgne F., Rousseau C., Leyrat C., Giral M., Chapal M., Barbin L., Laplaud D., Giraudeau B., Foucher Y. Régression logistique multivariée traditionnelle contre scores de propension : une étude pour mettre fin aux idées préconçues. 10e conférence francophone d'épidémiologie clinique (EPICLIN 2016) et 23e journées des statisticiens des centres de lutte contre le cancer, 25-27 mai 2016, Strasbourg, 2016.

  • 6. Fournier M.C., Blanche P., Foucher Y., Giral M., Dantan E. Construction d’un score pronostique dynamique et évaluation de ses performances : application en transplantation rénale. 10e conférence francophone d'épidémiologie clinique (EPICLIN 2016) et 23e journées des statisticiens des centres de lutte contre le cancer, 2016.

  • 7. Fournier M.C., Foucher Y., Giral M., Dantan E. Etude des déterminants de santé associés à l’évolution de la créatininémie et / ou du risque d’échec de greffe chez des patients transplantés rénaux : une approche par modélisation conjointe. GDR Statistique & Santé, 2015.

  • 8. Trébern-Launay K., Foucher Y., Giral M., Kessler M., Bayat-Makoei S., Briançon S., Kessler M. Risques compétitifs de décès et de transplantation pour les patients en insuffisance rénale terminale inscrits sur liste d’attente: un modèle de mélange ouvrant de nouvelles perspectives pour l’allocation des greffons. Conférence Francophone d’Epidémiologie Clinique (EPICLIN), Montpellier, France, May 20-22, 2015.

  • 9. Fournier M.C., Foucher Y., Giral M., Dantan E. Etude des déterminants de santé associés à l’évolution de la créatininémie et / ou du risque d’échec de greffe chez des patients transplantés rénaux : une approche par modélisation conjointe. EPICLIN, Montpellier, 20-22 mai 2015, 2015.

  • 10. Dantan E., Foucher Y., Giral M., Tessier P. Quel seuil de discrimination pour un test pronostique à des fins de médecine stratifiée ? Une approche pratique d’une théorie de la décision basée sur les QALYs. 9ème Conférence Francophone d’Epidémiologie Clinique (EPICLIN), 20-22 mai 2015, Montpellier, 2015.

  • 11. Gillaizeau F., Dantan E., Giral M., Foucher Y. A multistate additive relative survival semi-Markov model. 46e Journées de Statistique de la SFdS, 2-6 juin 2014, Rennes, 2014.

  • 12. Dantan E., Combescure C., Lorent M., Ashton-Chess J., Daguin P., Classe J.M., Giral M., Foucher Y. An original approach to evaluate the prognostic marker capacity using published survival curves. 46e Journées de Statistique de la SFdS, 2-6 juin 2014, Rennes, 2014.

  • 13. Lorent M., Giral M., Foucher Y. Courbes ROC nettes dépendantes du temps : une méthode d’évaluation de la capacité d’un marqueur à prédire la mortalité spécifiquement liée à une maladie. Société Française de Statistique (SFDS), Juin 2014, Rennes (France), 2014.

  • 14. Lorent M., Foucher Y., Giral M. Courbes ROC nettes dépendantes du temps : méthode d’évaluation de la capacité d’un marqueur à prédire la mortalité liée à l’insuffisance rénale terminale chez des patients transplantés rénaux. Société Francophone de transplantation (SFT), Décembre 2012, Nantes (France), 2012.

  • 15. Foucher Y., Giral M., Soulillou J.P., Daurès J.P. Modèle semi-Markovien avec double censure par intervalle et test d'adéquation pour l'étude de l'évolution des patients transplantés rénaux. 39ème journées de statistique (SFDS), 2007.

  • 16. Foucher Y., Giral M., Dellamonica P., Daurès J.P. Analyse des données de survie par un modèle de fragilité paramétrique. 37ème journées de statistique (SFDS), 2005.

Poster dans un colloque national (idpers=180)

  • 1. Enjalbert L., Hardouin J.B., Blanchin M., Giral M., Meurette A., Sébille V. Évaluation de l’évolution de la qualité de vie des patients préemptifs et dialysés sur liste d’attente d’une transplantation rénale : étude de l’invariance de la mesure. 12e Conférence francophone d’Épidémiologie clinique 25e Journée des statisticiens des Centres de lutte contre le cancer, 30 mai-1er juin 2018, Nice, France, Revues d'Epidémiologie et de Santé Publique 2018, 66(3): S150, 2018.

  • 2. Dantan E., Foucher Y., Combescure C., Lorent M., Ashton-Chess J., Daguin P., Giral M., Classe J.M. Evaluation a posteriori des capacités pronostiques d’un marqueur : Application au cancer du sein. 8èmes Journées du Cancéropôle GO, 2014.

  • 3. Trébern-Launay K., Foucher Y., Dantal J., Giral M. A multiplicative-regression model to compare the risk factors associated with time to graft failure between a first and second renal transplant. Congrès de la Société Francophone de Transplantation (SFT), Nantes, France, December 12-15, 2012.

  • 4. Foucher Y., Soulillou J.P., Giral M. Courbes Roc Multi-états et temps dépendantes. Biostatistique et mesures subjectives en santé, Nantes, 2008, 2008.

  • 5. Miqueu P., Guillet M., Giral M., Ruiz C., Braudeau C., Hernandez M., Le Moine B., Sawitzki A., Warrens A., Legendre C., Goldman M., Volk H.-D., Wood K. Lechler R.-I., Sébille V., Bertrand D. Soulillou J.-P., Brouard S.. T Cell Repertoire analysis of stable kidney graft recipients for detection of low and high risk of chronic rejection. Biostatistique et mesures subjectives en santé, Nantes, 2008, 2008.



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