UMR INSERM 1246 - SPHERE
MethodS in Patients-centered outcomes
and HEalth ResEarch

INSERM Univ Nantes Univ Tours
EA4275-SPHERE
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Life of the unit

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Next seminars

25 mai 2018 à préciser à préciser

22 juin 2018 à préciser Journée Scientifique conjointe de l'unité SPHERE et de l'unité ECEVE

Last publications

15 mai 2018 Nadal M, Levy M, Bakhsh A, Joly A, Maruani A, Vaillant L, Erra B, Samimi M (2018) Salivary scintigraphy for Sjögren's syndrome in patients with xerostomia: A retrospective study. Oral Dis, 24(4): 552-60.

15 avril 2018 Moawad S, Mahé E, Aubert- Wastiaux H, Phan A, Maruani A, Chiaverini C, Bodemer C, Mazereeuw-Hautier J, Lasek-Duriez A, Droitcourt C, Barbarot S, Beauchet A, Bursztejn A, Groupe de Recherche de la Société Française de Dermatologie Pédiatrique (2018) Topical Corticosteroid Concerns Among Parents of Children with Psoriasis versus Atopic Dermatitis: A French Multicenter Cross-Sectional Study. Am J Clin Dermatol, 19(2): 261-5.

01 avril 2018 Diguisto C, Winer N, Descriaud C, Tavernier E, Weymuller V, Giraudeau B, Perrotin F (2018) Amnioinfusion for women with a singleton breech presentation and a previous failed external cephalic version: a randomized controlled trial. J Matern Fetal Neonatal Med, 31(8): 993-9.

01 mars 2018 Contentin L, Frasca D, Tavernier E, Feuillet F, Foucher Y, Giraudeau B (2018) Ventilator-Free Day Outcomes Can Be Misleading. Crit Care Med, 46(3): 425-429.

01 mars 2018 Beslon V, Moreau P, Maruani A, Maisonneuve H, Giraudeau B, Fournier J (2018) Effects of Discontinuation of Urate-Lowering Therapy: A Systematic Review. J Gen Intern Med, 33(3): 358-66.

Updated

19 avril 2018

Scientific project of the INSERM Unit U1246 SPHERE

welcome xhdzyPsychological, cultural, behavioural, environmental and economic factors are recognized as potentially influencing the health and patients’ outcomes. However, in epidemiology and clinical research, addressing these "unique individual circumstances" remains a challenge. Researchers, physicians and policy-makers are indeed often faced with problems in measuring and interpreting patients' experiences, their adaptation to the disease, their relationships with their environment, their preferences and feelings, and the impact that the perception of their disease can have on their prognosis.

The unit SPHERE aims to promote patient-centred methodological research and to reinforce the contribution of patients-reported data (quality of life, fatigue, well-being…) in decision-making and assessment of care. Our scientific project takes place within three interacting axes developed in an interdisciplinary perspective: 1) measurement and interpretation of patients' perception and experience, 2) real-life evaluation taking into account the patient's environment, and 3) patient-centred stratified medicine. The objectives of the 3 axes are to propose adapted methodologies to better evaluate and understand patients’ adaptation to their disease and to provide improved interpretation of patients-reported outcomes, to take into account the environment of the patient in the pragmatic evaluation of patient’s management and prognosis, to integrate patients’ perspectives and preferences into medical decision making and prognostic evaluation.


New PhD and Master students

  • Marion Kerioui : Estimation des paramètres d’un modèle conjoint de données longitudinales non-linéaires et de survie par une méthode bayésienne (2018)
  • Julie Paul : Etude des données de qualité de vie de l'essai clinique CORTI-TC (Traitement de l'insuffisance surrénale secondaire à un traumatisme crânien grave) (2018)
  • Maxime Guettier : Facteurs prédictifs d'échec de traitement d'une infection sur prothèse (2018)
  • Samuel Tessier : Création d’une application R shiny pour l’obtention automatique d’un flow-chart dans le logiciel Plug-Stat® (2018)
  • Solenne Martin : Etude longitudinale des changements comportementaux, psychologiques et sociologiques après un cancer (ELCCA II) (2018)

level-1 Master’s degree in “Bioinformatics – Biostatistics”

welcome xhdzyIn 2012, a new level-1 Master’s degree in “Bioinformatics – Biostatistics” has been created. This Master offers the opportunity to pursue in two different level-2 Masters’ degrees: 1) “Modeling in Clinical Pharmacology and Epidemiology or 2) “Bioinformatics”

For more details, clic here, and you can contact Jean-Benoit Hardouin (referent for Biostatistiqcs), or Christine Sinoquet (referent for Bioinformatics).



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