UMR INSERM 1246 - SPHERE
MethodS in Patients-centered outcomes
and HEalth ResEarch

INSERM Univ Nantes Univ Tours
EA4275-SPHERE
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Last publications

15 janvier 2021 Castro-Calvo J, King D, Stein D, Brand M, Carmi L, Chamberlain S, Demetrovics Z, Fineberg N, Rumpf H, Yücel M, Achab S, Ambekar A, Bahar N, Blaszczynski A, Bowden-Jones H, Carbonell X, Chan E, Ko C, deTimary P, Dufour M, Grall-Bronnec M, Lee H, Higuchi S, Jiménez-Murcia S, Király O, Kuss D, Long J, Müller A, Pallanti S, Potenza M, Rahimi-Movaghar A, Saunders JB, Schimmenti A, Lee SY, Siste K, Spritzer DT, Starcevic V, Weinstein A, Wölfling K, Billieux J (2021) Expert appraisal of criteria for assessing gaming disorder: an international Delphi study. : Online.

04 janvier 2021 Le Borgne F, Chatton A, Léger M, Lenain R, Foucher Y (2021)

01 décembre 2020 Chauchard E, Mariez J, Grall-Bronnec M, Challet G (2020) Buying-Shopping Disorder among Women: The Role of Vulnerability to Marketing, Buying Motives, Impulsivity, and Self-Esteem. Eur Addict Res: Online.

17 novembre 2020 Challet G, Grall-Bronnec M, Saillard A, Leboucher J, Donnio Y, Pere M, Caillon J (2020) Impact of Wagering Inducements on the Gambling Behaviors, Cognitions, and Emotions of Online Gamblers: A Randomized Controlled Study. Front. Psychiatry, 11: 593789.

02 octobre 2020 Jobert A, Laforgue E, Grall-Bronnec M, Rousselet M, Pere M, Jolliet P, FAN network , Feuillet F, Victorri-Vigneau C (2020) Benzodiazepine withdrawal in older people: what is the prevalence, what are the signs, and which patients? European journal of clinical pharmacology. Eur J Clin Pharmacol: Online.

Updated

18 février 2021

Scientific project of the INSERM Unit U1246 SPHERE

welcome xhdzyPsychological, cultural, behavioural, environmental and economic factors are recognized as potentially influencing the health and patients’ outcomes. However, in epidemiology and clinical research, addressing these "unique individual circumstances" remains a challenge. Researchers, physicians and policy-makers are indeed often faced with problems in measuring and interpreting patients' experiences, their adaptation to the disease, their relationships with their environment, their preferences and feelings, and the impact that the perception of their disease can have on their prognosis.

The unit SPHERE aims to promote patient-centred methodological research and to reinforce the contribution of patients-reported data (quality of life, fatigue, well-being…) in decision-making and assessment of care. Our scientific project takes place within three interacting axes developed in an interdisciplinary perspective: 1) measurement and interpretation of patients' perception and experience, 2) real-life evaluation taking into account the patient's environment, and 3) patient-centred stratified medicine. The objectives of the 3 axes are to propose adapted methodologies to better evaluate and understand patients’ adaptation to their disease and to provide improved interpretation of patients-reported outcomes, to take into account the environment of the patient in the pragmatic evaluation of patient’s management and prognosis, to integrate patients’ perspectives and preferences into medical decision making and prognostic evaluation.


Le LabCom RISCA

LabCom RISCALe laboratoire SPHERE et la société IDBC (groupe A2com) ont décidé de créer ensemble le Laboratoire Commun RISCA (Research in Informatics and Statistics for Cohort-based Analyses). Ce LabCom est financé par l'ANR pour 5 ans (2017-2021).

New PhD and Master students

  • Yseulys Dubuy : Définition et validation d’une méthode de détection du Response-Shift au niveau individuel à l’aide des erreurs de Guttman (2019)
  • Arthur Chatton : Inférence causale à partir de données observationnelles et censurées : l’intelligence artificielle au service du biostatisticien, épidémiologiste et clinicien (2019-2022)
  • Marion Kerioui : Estimation des paramètres d’un modèle conjoint de données longitudinales non-linéaires et de survie par une méthode bayésienne (2018)
  • Julie Paul : Etude des données de qualité de vie de l'essai clinique CORTI-TC (Traitement de l'insuffisance surrénale secondaire à un traumatisme crânien grave) (2018)
  • Maxime Guettier : Facteurs prédictifs d'échec de traitement d'une infection sur prothèse (2018)

level-1 Master’s degree in “Bioinformatics – Biostatistics”

welcome xhdzyIn 2012, a new level-1 Master’s degree in “Bioinformatics – Biostatistics” has been created. This Master offers the opportunity to pursue in two different level-2 Masters’ degrees: 1) “Modeling in Clinical Pharmacology and Epidemiology or 2) “Bioinformatics”

For more details, clic here, and you can contact Jean-Benoit Hardouin (referent for Biostatistiqcs), or Christine Sinoquet (referent for Bioinformatics).



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