UMR INSERM 1246 - SPHERE
MethodS in Patients-centered outcomes
and HEalth ResEarch

INSERM Univ Nantes Univ Tours
EA4275-SPHERE
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Research

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AnaQol Project PRO-online R Packages Online R-package

Life of the unit

Projects Collaborations PhD thesis Traineeships Traineeships propositions Seminars

Next seminars

28 février 2019 Marianne Bourdon et Cédric Faquet état des lieux des différentes méthodes d’analyse qualitative

29 mars 2019 à définir à définir

Last publications

15 février 2019 Goldstein C, Giraudeau B, Weijer C, Taljaard M (2019) In reply: When and how should we cluster and cross over: methodological and ethical issues (letters 1 and 2). Can J Anaesth, 66(2): 239-40.

01 février 2019 Cornillier H, Giraudeau B, Samimi M, Munck S, Hacard F, Jonville-Bera AP, Jegou M, d'Acremont G, Pham B, Chosidow O, Maruani A (2019) Effect of Diet in Chronic Spontaneous Urticaria: A Systematic Review. Acta Derm Venereol, 99(2): 127-32.

01 février 2019 Hanson C, Sautenet B, Craig J, Chapman J, Knoll G, Reddy B, Tong A (2019) Informative for Decision-making? The Spectrum and Consistency of Outcomes Following Living Kidney Donation Reported in Trials and Observational Studies. Transplantation, 103(2): 284-90.

31 janvier 2019 El Habnouni C, Cornillier H, Tauveron V, Guyétant S, Maruani A (2019) Rapidly Growing Tumour on the Forearm of an 83-year-old Woman: A Quiz. Acta Derm Venereol, 99(1): 121-2.

31 janvier 2019 Tallegas M, Fraitag S, Binet A, Orbach D, Jourdain A, Reynaud S, Pierron G, Machet M, Maruani A (2019) Novel KHDRBS1-NTRK3 rearrangement in a congenital pediatric CD34-positive skin tumor: a case report. Virchows Arch, 474(1): 111-5.

Updated

20 février 2019

Scientific project of the INSERM Unit U1246 SPHERE

welcome xhdzyPsychological, cultural, behavioural, environmental and economic factors are recognized as potentially influencing the health and patients’ outcomes. However, in epidemiology and clinical research, addressing these "unique individual circumstances" remains a challenge. Researchers, physicians and policy-makers are indeed often faced with problems in measuring and interpreting patients' experiences, their adaptation to the disease, their relationships with their environment, their preferences and feelings, and the impact that the perception of their disease can have on their prognosis.

The unit SPHERE aims to promote patient-centred methodological research and to reinforce the contribution of patients-reported data (quality of life, fatigue, well-being…) in decision-making and assessment of care. Our scientific project takes place within three interacting axes developed in an interdisciplinary perspective: 1) measurement and interpretation of patients' perception and experience, 2) real-life evaluation taking into account the patient's environment, and 3) patient-centred stratified medicine. The objectives of the 3 axes are to propose adapted methodologies to better evaluate and understand patients’ adaptation to their disease and to provide improved interpretation of patients-reported outcomes, to take into account the environment of the patient in the pragmatic evaluation of patient’s management and prognosis, to integrate patients’ perspectives and preferences into medical decision making and prognostic evaluation.


Le LabCom RISCA

LabCom RISCALe laboratoire SPHERE et la société IDBC (groupe A2com) ont décidé de créer ensemble le Laboratoire Commun RISCA (Research in Informatics and Statistics for Cohort-based Analyses). Ce LabCom est financé par l'ANR pour 5 ans (2017-2021).

New PhD and Master students

  • Marion Kerioui : Estimation des paramètres d’un modèle conjoint de données longitudinales non-linéaires et de survie par une méthode bayésienne (2018)
  • Julie Paul : Etude des données de qualité de vie de l'essai clinique CORTI-TC (Traitement de l'insuffisance surrénale secondaire à un traumatisme crânien grave) (2018)
  • Maxime Guettier : Facteurs prédictifs d'échec de traitement d'une infection sur prothèse (2018)
  • Samuel Tessier : Création d’une application R shiny pour l’obtention automatique d’un flow-chart dans le logiciel Plug-Stat® (2018)
  • Solenne Martin : Etude longitudinale des changements comportementaux, psychologiques et sociologiques après un cancer (ELCCA II) (2018)

level-1 Master’s degree in “Bioinformatics – Biostatistics”

welcome xhdzyIn 2012, a new level-1 Master’s degree in “Bioinformatics – Biostatistics” has been created. This Master offers the opportunity to pursue in two different level-2 Masters’ degrees: 1) “Modeling in Clinical Pharmacology and Epidemiology or 2) “Bioinformatics”

For more details, clic here, and you can contact Jean-Benoit Hardouin (referent for Biostatistiqcs), or Christine Sinoquet (referent for Bioinformatics).



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